AGT and Hypertension: For example, treatment of mice with mitoTEMPO reduces hypertension induced by both AngII or deoxycorticosterone acetate (DOCA) salt [76], reduces the mitochondrial superoxide anion and 3-nitrotyrosine, serum glucose levels and diastolic dysfunction observed in high-fat diet mice [34], decreases mitochondrial ROS production, and prevents cardiomyocytes hypertrophy in diabetic mouse hearts [77].