Zhang et al. employed a rodent model of aortic stenosis-induced pressure overload and while they did not report MMP or TIMP cardiac tissue mRNA or protein levels, 8 weeks after induction of pressure overload, MMP1, MMP2, MMP9 and TIMP1 protein levels were significantly increased in the circulation compared to time-matched controls [87]. The gene discussed is MMP1; the disease is aortic stenosis.