In conductance with the previous literature, the present study aimed to assess the protective effects of P. ostreatus and A. bisporus aqueous extracts and carvedilol on hyperoxaluria-induced nephrolithiasis in Wistar rats and to elucidate the probable implications of NF-κB, NF-κB p65, NF-κB p50, p53, Bcl-2, Bax and Bak in their mechanisms of action. The gene discussed is BCL2; the disease is Hyperoxaluria.