INS and Myocardial fibrosis: -↔ blood glucose, pancreas insulin content-↔ body weight-↓ left ventricular dysfunction-↓ oxidative and nitrative stress in heart-↓ inflammation and NF-κB activation in heart-↓ apoptosis and MAPK activation in heart-↓ myocardial fibrosis-↓ activation of NF-κB, JNK, p38 and p38α MAPK in heart-↑ activation of Akt in heart