Trehalose dosing in mice has shown therapeutic effects, concomitant with autophagy induction, in a wide range of neurodegenerative disease models, including AD, PD, frontotemporal lobar dementia (FTLD), HD, SCA17, PrP and amyotrophic lateral sclerosis (ALS) [145]. The gene discussed is PRNP; the disease is amyotrophic lateral sclerosis.