Four clinical trial studies determined adiponectin concentrations in dogs during obesity development (16.8%) [27,28,29,30], and in this case the circulating adiponectin concentrations were significantly reduced when dogs became obese when compared to the initial condition (SMD = 3.31, 95% CI: 0.55–6.08, p = 0.020). Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.