In the same study, the investigators saw decreased CD31+ (tumor angiogenesis), with marked increase of CD8+ cytotoxic T-cells, CD11c+ DCs, and PD-L1+ in the TME of a Renca Balb/c model, showcasing even more drastic TME changes than a MMTV-PyMT orthotopic model. This evidence concerns the gene CD8A and neoplasm.