On the other hand, exercise preconditioning suppressed HF+DSS-induced up-regulation of inflammatory and chemotactic cytokines (i.e., IL-6, GRO-α, and MCP-1) and HF+DSS-induced down-regulation of adiponectin, as shown in EX+HF+DSS vs. HF+DSS. This evidence concerns the gene CCL2 and hydrops fetalis.