The histological analysis of MOC1 tumor one week after treatment showed that infiltration of CD8+ and CD4+ T-cells into the tumor bed dramatically increased after CTLA4 immune-checkpoint blockade alone and combined regimen of CD44-targeted NIR-PIT with CTLA4 immune-checkpoint blockade (Figure 4 and Supplementary Figure S1). The gene discussed is CD44; the disease is neoplasm.