This kind of Vertical-Omics or Multi-Omics are useful to identify the most significant genes viz., HMGB1, YWHAZ, PIK3R1, STAT3, MAPK1, CBX5, CAPZB, THBS1, TNFRSF10B, RCOR1 (target genes of miRNAs) related to ischemic stroke pathogenesis underlying the inflammation, blood coagulation, atherosclerosis, etc. [21,170]. This evidence concerns the gene HMGB1 and atherosclerosis.