MiR-155 is capable of inducing the expression of TNF-α and IL-1β in cerebral ischemia by regulating TLR4 activity, consequently suppressing the expression of inflammatory mediators viz., suppressor of cytokine signaling 1 (SOCS1) and myeloid differentiation primary response protein 88 (MyD88). Here, SOCS1 is linked to brain ischemia.