CLDN5 and stroke disorder: Experimental models of medial cerebral artery occlusion (MCAO) have shown that the upregulation of miR-150 could increase BBB permeability; the overexpression of miR-150 in microvascular endothelial cells mitigates the expression of claudin-5, a tight junction protein; the low levels of claudin-5 eventually evokes extensive rise in “endothelial permeability” and neural cell death in oxygen-glucose deprivation condition (OGD) during stroke [129].