Sphingolipid signaling pathway and sphingolipid metabolism are also found in the same cluster with Ras signaling and mTOR signaling pathways in fibroblast “ataxia” datasets (Figure 3C), which are directly associated with Rap1 signaling and autophagy based on KEGG reference pathway-to-pathway network. The gene discussed is MTOR; the disease is cerebellar ataxia.