In the present study, the in-depth analysis of the relationship between polymorphic genotypes of SOD rs4880 and clinic-pathologic features of EGFR-mutated lung adenocarcinoma is particularly important, because SOD polymorphism-mediated stratification of EGFR mutation-related phenotypes, which are considered to be a major predictor of therapeutic responsiveness, can be more advantageous and effective in predicting lung cancer risk as well as therapeutic responsiveness. Here, EGFR is linked to lung adenocarcinoma.