In the context of B cell malignancies, CLL-derived exosomes show the phenotypic characteristics of normal exosomes, such as CD63 and CD81 expression, but they additionally express IgM, CD19 and Lyn; this could be used to distinguish the neoplastic B cells-derived exosomes among the assorted groups of circulating EVs [52]. The gene discussed is CD19; the disease is B-cell chronic lymphocytic leukemia.