LRRK2 and Parkinson disease: Single-gene mutations leading to PD can be divided into two types: Autosomal Dominant Parkinson, including the α-synuclein non-A4 component of the amyloid precursor (NAC/α-synuclein) and leucine repeat rich kinase 2 (LRRK2) [5], and Autosomal Recessive Parkinson (AR-JP), including PARKIN, DJ-1, P type ATPase (ATP13A2), and (PTEN)-induced kinase 1 (PINK-1).