Even if the mechanism that drives miR-17/92 expression remains poorly understood, studies demonstrated that up-regulation of miRNAs belonging to the miR-17-92 cluster in unmutated IGHV CLL is preceded by induction of MYC, providing a link between MYC, B-cell receptor (BCR) activation and miR-transcription in CLL [11,13]. Here, MYC is linked to B-cell chronic lymphocytic leukemia.