On the other hand, overexpression of these miRNAs sensitize CLL cells to fludarabine-mediated cell death by targeting key mediators such as B-cell lymphoma− 2 (BCL− 2), myeloid cell leukemia-1 (MCL-1) and X-linked inhibitor of apoptosis (XIAP) proteins [87]. This evidence concerns the gene MCL1 and B-cell chronic lymphocytic leukemia.