LincRNA-p21 (long intergenic non-coding RNA p21, located 17 kb upstream of p21) and NEAT1 (nuclear enriched abundant transcript 1) are two p53-regulated lncRNAs induced in response to DNA damage identified in primary CLL cells only when a functional form of p53 is present [32]. This evidence concerns the gene CDKN1A and B-cell chronic lymphocytic leukemia.