Moreover, through EB1/EB3 interactions, NAP enhances Tau-microtubule binding, protecting against tauopathy [23,24], which has also been found in the SOD1-G93A mouse model of the neuromuscular disorder, amyotrophic lateral sclerosis (ALS) [36]. The gene discussed is CTNNBL1; the disease is amyotrophic lateral sclerosis.