ADCYAP1R1 and hyperinsulinemic hypoglycemia, familial, 4: These findings are of significant interest, as intra-bladder administration of the PAC1 receptor antagonist, PACAP(6–38), reduces urinary bladder frequency and pelvic sensitivity in mice exposed to repeated variate stress [48], with PACAP ameliorating Adnp-deficiency exacerbated stress response [3].