In this study, the relationship between the methylation profile of a panel of 13 genes (ZAP70, ITGA4, KIF1A, PARP15, EPHX3, NTM, LRRTM1, FLI1, MIR193, LINC00599 TERT, MIR296, and GP1BB) and their role in predicting some factors (tumor size, lymph node involvement, AE), not otherwise identifiable from pathological pre-operative diagnosis was investigated. This evidence concerns the gene EPHX3 and neoplasm.