Patients expressing the IFNλ4 variant with one amino acid change that reduces IFNλ4 secretion was found increased in frequency in HCV‐related diseases compared to HCC PDCD1 mRNA levels in HCC tissue were significantly higher in cases carrying the PD‐1.3 A or the PD‐1.7 G allele (P = .0025 and P = .0167). The gene discussed is PDCD1; the disease is hepatocellular carcinoma.