Interestingly, HCC biopsies from patients carrying the PD‐1.3 (rs11568821‐A allele) and PD‐1.7 (rs7421861‐G allele) polymorphisms expressed higher levels of PDCD1 mRNA; this association was not found in PBMCs from the same patients. The gene discussed is PDCD1; the disease is hepatocellular carcinoma.