In particular, patients with HCC had a higher frequency of PD‐1.5 C/C alleles (37% vs 26%, OR = 0.61, P = .035) and a lower frequency of PD‐1.7 A/A (53% vs 38%, OR = 1.86, P < .005) compared to those with CHC. This evidence concerns the gene PDCD1 and cryohydrocytosis.