We observed higher levels (>10%) of PD‐1hi expression on CD4+T cells and lower levels of PD‐L1hi (≤1%) on IgM+ CD19+ B cells in patients with HCV‐related MC compared to patients with HCC without HCV‐infection, suggesting an alteration in the control of B cell‐T cell interaction in our MC cases. Here, CD40LG is linked to hepatocellular carcinoma.