The PD‐1.7 A/A allele distribution in liver diseases has shown to follow a negative trend with disease severity meaning a lower frequency in HCC (38%) followed by cirrhosis (47%), CHC with severe fibrosis (51%) and CHC with mild‐moderate fibrosis (52%); chi‐squared test for trend for PD‐1.7 = 5.596, P = .018 (Table S5). This evidence concerns the gene PDCD1 and cryohydrocytosis.