Several risk factors associated with progression to MM have been suggested, with a non‐IgG M‐protein,5, 6 M‐spike >1.5 g/dL5, 6 and abnormal serum free light chain (sFLC) ratios (FLCr)6 incorporated into current International Myeloma Working Group (IMWG) risk criteria.2 The gene discussed is MYOM2; the disease is plasma cell myeloma.