FGF1 and central nervous system cancer: In C6 glioma cells (De Vuyst et al., 2007) and HeLa cells (Schalper et al., 2008) transfected with Cx43, as well as in spinal astrocytes (Garré et al., 2010), FGF1 or FGF2 induces a transient opening of the formed Cx43 HCs, through which ATP is released.