To examine the in vivo protection of genotype C1 EV-A71-neutralizing MAbs 16-2-11B, 17-1-12A, and 16-3-4D, we established a mouse infection model, in which three-week-old human scavenger receptor class B member 2 (hSCARB2)-transgenic mice (C57BL/6 background) were infected intraperitoneally with 2018–2019 EV-A71 (TW-5011-2018) [28]. The gene discussed is SCARB2; the disease is infection.