GH1 and hypothyroidism: It therefore appears that there is a difference between CUG in GHD versus conditions where the cause can be removed completely (e.g. hypothyroidism, removal of tumour, etc): in GHD CUG is dependent on GH dose, and in each individual child it is impossible to know what the GH dose should be to mimic the “natural” GH secretion during the various phases of CUG observed in children with other conditions.