TGFB1 and type 1 diabetes mellitus: Nagelkerke R2 showed that each predictor TGF-β1 mRNA, flRAGE mRNA, sRAGE protein, TGF-β1 protein and CRP, in univariate analysis could explain the variation in T1D development by 24.1%, 17.8%, 14%, 8.2% and 6.6%, respectively.