Initially, advanced glycation end product receptor (RAGE) has been considered a central regulator of neural system (Cho, Xie, & Cai, 2018; Osgood, Miller, Messier, Gonzalez, & Silverberg, 2017) and has been suggested to play an important role in aging‐related arterial diseases (Senatus & Schmidt, 2017; Yamagishi & Matsui, 2018). This evidence concerns the gene AGER and arterial disorder.