TMPRSS2 and neoplasm: In fact, the androgen-responsive element is the only known transcription promoter for the TMPRSS2 gene and this has been strongly associated with the acquired tumor growth and invasiveness of prostate cancer, particularly when TMPRSS2-ERG gene fusion is observed (Reviewed in [41]) and suppressing circulating androgens in men might reduce its activity and reduce the severity of COVID infection [42].