In recessive model, the random-effects model was used to analyze, and the result showed that UGT1A1*6 polymorphism was the risk of IRI-induced severe neutropenia (GG vs. AA+GA: OR = 0.40, 95% CI: 0.22–0.71, P=0.00). This evidence concerns the gene UGT1A1 and Decreased total neutrophil count.