In different models present different results, we found the significant association in all genetic models between UGT1A1*6 polymorphism and IRI-induced neutropenia in China: (1) allele model: (G vs. A: OR = 0.60, 95% CI: 0.47–0.76, P=0.00); (2) homozygote model: (GG vs. AA: OR = 0.29, 95% CI: 0.17–0.50, P=0.00); (3) heterozygote model: (GA vs. AA: OR = 0.42, 95% CI: 0.24–0.74, P=0.00); (4) dominant model: (GG+GA vs. AA: OR = 0.33, 95% CI: 0.19–0.55, P=0.00); (5) recessive model (GG vs. AA+GA:OR = 0.40, 95% CI: 0.22–0.71, P=0.00). This evidence concerns the gene UGT1A1 and neutropenia.