Our results showed that UGT1A1*6 polymorphism was associated with IRI-induced severe neutropenia (Figure 5.1): (1) allele model: (G vs. A: OR = 0.57, 95% CI: 0.46–0.71, P=0.00); (2) homozygote model: (GG vs. AA: OR = 0.28, 95% CI: 0.17–0.45, P=0.00); (3) heterozygote model: (GA vs. AA: OR = 0.42, 95% CI: 0.26–0.70, P=0.00); (4) dominant model: (GG+GA vs. AA: OR = 0.32, 95% CI: 0.20–0.52, P=0.00). The gene discussed is UGT1A1; the disease is neutropenia.