Specifically: rs9288999 of ZBTB20 is a protective factor (OR < 1) for the risk of gastric cancer under the allele model (G vs. A, OR = 0.73, CI = 0.61–0.87, P=0.001), homozygous model (GG vs. AA, OR = 0.48, CI = 0.33–0.71, P=0.0003), dominant model (GG-GA vs. AA, OR = 0.72, CI = 0.56–0.94, P=0.014), recessive model (GG vs. GA-AA, OR = 0.55, CI = 0.38–0.78, P=0.001) and additive model (OR = 0.72, CI = 0.60–0.87, P=0.0005). This evidence concerns the gene ZBTB20 and gastric cancer.