GTF2IRD1 and pachyonychia congenita: Importantly, KM survival analysis based on the TCGA PC cohort, the GSE62452 cohort, and the GSE79668 cohort demonstrated that patients with higher expression of GTF2IRD1 had a shorter OS than those with lower expression of GTF2IRD1 (P-value <0.05) (Figure 1E–G).