Furthermore, we conducted correlation analysis between GTF2IRD1 and the marker genes from TILs using the GEPIA database, which demonstrated GTF2IRD1 overexpression significantly correlated with low expression of these gene markers (e.g. CD8A, CD3D, and CD3E) in PC, but not significant in normal pancreatic tissues (Table 5). The gene discussed is CD3E; the disease is pachyonychia congenita.