For instance, lncRNA CCAT2, activated by E2F1, plays a cancer-promoting role in PA by interacting with PTTG1.6 LncRNA small nucleolar RNA host gene 6 (SNHG6) was validated to be oncogenic in several cancers, including hepatocellular carcinoma and colorectal cancer.7,8 Unfortunately, the biological function and mechanism of SNHG6 in IPA remain poorly understood. The gene discussed is E2F1; the disease is cancer.