In a final model comprising the strongest predictors overall as well as diastolic BP, NYHA class, Lg creatinine, Lg hs‐CRP, and Lg MPO, FGF23 [adjusted HR 1.665; 95% confidence interval (CI) 1.284–2.160; P < 0.0001] remained an independent predictor along with Lg BNP (HR 1.433, CI 1.053–1.951; P = 0.022) and prior HF hospitalization (HR 2.058; CI 1.074–3.942; P = 0.030). The gene discussed is MPO; the disease is hydrops fetalis.