CBS and diabetes mellitus: Thus, the immunoassays revealed the down‐regulation of Cbs (~2.5‐fold, P ≤ .01) and the up‐regulation of Suox (~1.6‐fold, P ≤ .01) and Tst (~1.5‐fold, P ≤ .01) macromolecules in the diabetic kidney (Figure 4B).