For this reason, interrupting NEMO/IKKγ has severe consequences for tissue homeostasis, and mutation of NEMO/IKKγ can lead to hereditary human diseases such as incontinentia pigmenti, anhidrotic ectodermal dysplasia with immunodeficiency (EDA‐ID), and immunodeficiency 33 (Filipe‐Santos et al, 2006; Fusco et al, 2015). This evidence concerns the gene IKBKG and immune system disorder.