TNF‐α, IL‐6 and IL‐1β, principally released by innate immune cells, can be one of the major driving forces for cytokine release syndrome and severe systemic inflammatory responses in patients with advanced stages of SARS‐CoV‐2 infection,76, 77, 78, 79 and some of them could be one of the underlying mechanisms responsible for lymphopenia and/or inadequate Th1 responses in these patients.39, 80. This evidence concerns the gene TNF and lymphopenia.