There is a circRASSF2/miR-302b-3p/insulin-like growth factor 1 receptor (IGF-1R) axis in LSCC progression. Importantly, study demonstrated that circRASSF2 was up-regulated in serum exosomes from LSCC patients, indicating the significance of exosomal circRNAs in tumor cell proliferation [96]. The gene discussed is IGF1R; the disease is neoplasm.