CircPUM1 up-regulated the expression of nuclear factor kappa B (NF-κB) and MMP2 by sponging miR-615-5p and miR-6753-5p to promote ovarian cancer proliferation, migration and invasion, which also acts on the peritoneum and contributes to metastasis of cancer in the form of cancer-derived exosomes [90]. This evidence concerns the gene MMP2 and cancer.