Further, among the 6 prognostic hub genes, differential expressions of the genes encoding fatty acid-binding protein 5 (FABP5); involucrin (IVL); keratins 6A, 15, and 16 (KRT6A, KRT15, and KRT16); and tissue inhibitor of metalloproteinases 2 (TIMP2) was significantly associated with prognosis of patients with melanoma based on the survival analysis and COX models. This evidence concerns the gene IVL and melanoma.