We also analyzed two publicly available datasets from GEO (GSE10927 deposited by Giordano et al.)and EMBL-EBI (E-TABM-311 deposited by Reynies et al.)for the expression of APOBEC3B and observed that in both cohorts, there was a 5–6 fold higher expression in ACC compared to normal and benign adrenocortical tissue samples (p < 0.01) with no difference in expression between benign tumors and normal adrenocortical tissue samples (Figure 1B and 1C). This evidence concerns the gene APOBEC3B and benign neoplasm.