The administration of NF-κB inhibitor after acidic bile also resulted in a greater inhibitory effect on the “tumor suppressor” miR-34a and miR-451a, than its administration before acidic bile with significantly higher levels of miR-34a and miR-451a, in post-treated, relative to HM exposed to acidic bile alone or pre-treated with BAY 11-7082 (Figure 4B) (Table 2 and Supplementary Table 2). This evidence concerns the gene NFKB1 and neoplasm.