Cancer-related cytokines, such as Tnf, as well as Wnt5a [31, 32], an important mediator of an epithelial to mesenchymal transition (EMT) process [35] and previously shown to be rapidly induced by NF-κB, are both successfully inhibited by either pre- or post- topical administration of BAY 11-7082. This evidence concerns the gene NFKB1 and cancer.