In addition, the effectiveness of topical pre-application of BAY 11-7082 in inhibiting the acidic bile-induced transcriptional activation of cancer-related pro-inflammatory Il6 [22, 23, 35] and Ptgs2 [36], as similarly observed by its co-administration on HM [24], indicates their activation mediated by NF-κB occurs early. The gene discussed is NFKB1; the disease is cancer.