Our data further show that topical pre-administration of NF-κB inhibitor on murine HM can be significantly more effective than its post-administration, in inhibiting the upregulation of NF-κB transcriptional factor, Rela, anti-apoptotic or cell proliferation factors, Bcl2, Stat3, Egfr, Wnt5a, Tnf, Il6 and Ptgs2, as well as “oncomirs” miR-21, miR-155, miR-192 and “tumor suppressor” miR-99a, caused by acidic bile exposure. Here, IL6 is linked to neoplasm.