During this process NF-κB interacts with a complex network of other cancer related transcriptional factors, cytokines and growth factors and miRNA molecules, including EGFR/Ras/RAF/MAPK, Akt/PI3K/mTOR, ΙΚΚ/NF-κB, STAT3, and wnt/β-catenin, miR-21, miR-34a, miR-451a and miR-99a [13–19]. The gene discussed is NFKB1; the disease is cancer.