When EE was adjusted for LBM by taking tumor mass into account (Supplementary Figure 3A–3B), no change in EE was detected in Ghsr+/+ tumor-bearing animals with or without ghrelin treatment; whereas Ghsr−/− animals exhibited higher EE levels with tumor implantation in comparison to Ghsr+/+ (genotype effect: p = 0.001); although, only ghrelin-treated mice reached significance in pair-wise comparisons. This evidence concerns the gene GHSR and neoplasm.