CDH1 and ovarian cancer: Furthermore, ginsenoside Rb1 inhibited hypoxia-induced EMT by downregulating miR-25 in ovarian cancer cells, which abrogated the suppression of miR-25 on the expression of EP300 (a transcriptional activator of E-cadherin) and E-cadherin (an essential molecule for adhesion between epithelial cells), thereby leading to an anti-metastatic effect (77).