AKT1 and ovarian carcinoma: Furthermore, resveratrol downregulated the phosphorylation of AKT and GSK3β in a dose-dependent manner in ovarian cancer cells, as well as decreasing the activity of extracellular signal-regulating kinase (ERK), which subsequently suppressed the expression of cyclin D1, which facilitated cyclin-dependent kinases CDK4 or CDK6 in promoting cell cycle progression (52).