Multivariate analysis identified uTFF1 and uADAM12 as independent significant proteins for the diagnosis of GC (uTFF1: OR 1.033, 95% CI, 1.011–1.055, P = 0.003; uADAM12: OR 1.026, 95% CI 1.009–1.043, P = 0.003) as well as H. pylori-positive status (OR 3.717, 95% CI 1.502–9.259, P = 0.005), but uPGA3 and BARD1 were not significant. The gene discussed is BARD1; the disease is gastric cancer.