IGFBP1 and metabolic syndrome: Similarly, in the group with PreDM the subgroup with low IGFBP-1 levels (n = 32) at baseline had signs of the metabolic syndrome with decreased HDL and adiponectin as well as increased triglycerides, insulin, HOMA-IR and IGFSD compared to the subgroup with high IGFBP-1 (n = 13).