Since carbon metabolism is the most basic aspect of life and therefore an extensive network consisting of sub-pathways, we narrowed down our findings towards a consequentially central and a significant pathway that embrace the carbon metabolism pathway involving the molecular signatures KYNU, ADA, SOD2, CAT and ACE, further is also effectuated by potential drug methotrexate and is associated with IBD/ ReA/ IBD and ReA cohorts. Here, CAT is linked to inflammatory bowel disease.