The disease network constructed through our approach consists of 412 single connected essential protein interactors of KYNU, where 394 human essential protein interactors are found to be associated with IBD, while 3 of them (Adenosine Deaminase (ADA), Catalase (CAT) and Superoxide Dismutase 2 (SOD2)) are associated with both IBD and ReA. The gene discussed is SOD2; the disease is inflammatory bowel disease.