394 human essential protein interactors were found to be associated with IBD and similarly 3 essential protein interactors namely Adenosine Deaminase (ADA), Catalase (CAT) and Superoxide Dismutase 2 (SOD2) with both IBD and ReA from analysed datasets, published datasets and literature sources (see Supplementary Table S10 online). This evidence concerns the gene ADA and inflammatory bowel disease.