Further analysis demonstrated hyperglycemia caused a significant enhancement in the expression levels of Bax (fold change = 3.22, P = 0.0002) and Bcl-2 (fold change = 2.10, P = 0.0021) in the diabetic group, whereas in the case of QC and QCSPIONs treatments, the expression of Bax (fold change = 1.35, P = 0.0009 for QC and fold change = 1.59, P = 0.0025 for QCSPIONs) and Bcl-2 (fold change = 1.23, P = 0.0086 for QC and fold change = 1.34, P = 0.0150 for QCSPIONs) were significantly downregulated, which are almost the same level as the control group. The gene discussed is BAX; the disease is Hyperglycemia.