NFKB1 and Hyperglycemia: Hyperglycemia, through several mechanisms including glucose-mediated activation of protein kinase c (PKC) isoform, aldose reductase (AR) pathway, increased production of reactive oxygen species (ROS), and extra production of advanced glycation end products (AGEs) can cause nuclear translocation of NF-κB and generation of proinflammatory cytokines and further neuroinflammatory process8, 9.