In contrast, we found that four naturally occurring cancer-associated mutations within the SSSDS sequence inhibit or are predicted to inhibit RNF43-mediated repression of Wnt/β-catenin signalling (Figs. 1b, 2a, Supplementary Fig. 6b, c), suggesting that loss of RNF43 phospho-regulation contributes to tumorigenesis. The gene discussed is RNF43; the disease is cancer.