Study has shown that repressed TET2 expression is linked to promoted epithelial-mesenchymal-transition (EMT) phenotype and expansion of a breast cancer stem cell-like population with skewed asymmetric cell division in vitro10; however, the in vivo role that TET2 plays in regulation of mammary differentiation and tumorigenesis has yet to be determined. Here, TET2 is linked to breast carcinoma.