NTAN1 and neoplasm: HEVs, defined as the specific vessels in lymph nodes, are critical for the formation of TLSs and recruitment of naive B cells and T cells from blood to lymphatic tissues through bonding to L-selectin on the surface of naive lymphocytes and activation of B cells and T cells, which might help eliminate tumours.9,39,40 In the present study, we found that PNAd+ HEV is an indispensable subpopulation surrounding the TLS and is significantly associated with the prognosis of OSCC patients.