The MX2-depleted cells were more permissive to infection, with increases in viral reporter gene expression ranging from 3.0-fold to 12.7-fold for luciferase-encoding HIV-1LTR (Fig. 7B) and a 5.5-fold increase in infectivity observed for eGFP-encoding HIV-1LTR (Fig. 7C). The gene discussed is MX2; the disease is infection.