We recently showed that EspH, an EPEC type III secreted effector implicated in actin cytoskeleton remodeling (9, –, 11) and the inhibition of Rho GTPases (10, 12), also suppresses the MAPK/extracellular signal-regulated kinases 1/2 (ERK1/2) signaling pathway at longer infection times (13). Here, MAPK3 is linked to infection.