Cell infection with EPEC-map+MapΔMTS-EspH1–25 caused diminished pERK (Fig. 6D), pMEK (data not shown), pEGFR (Fig. 6E), and ADAM10 (Fig. 6F) activity, reaching intermediate values between those attained upon infection with EPEC-map and EPEC-map+Mapwt. This evidence concerns the gene ADAM10 and infection.