We collected reduced representation bisulfite sequencing (RRBS) data from T-ALL, BRCA, and CRC and whole-genome bisulfite sequencing (WGBS) data from LUAD and PRAD for their DNA methylation profiles in cancer cells and corresponding normal tissues, and focused on the subsets of lost or gained CTCF binding regions that have sufficient bisulfite sequencing reads to call DNA methylation levels (Fig. 4a,b). This evidence concerns the gene CTCF and acute lymphoblastic leukemia.