Furthermore, beyond the identified T-ALLgained CTCF sites, we found a genome-wide positive correlation between CTCF binding specificity in T-ALL and co-occurrence of NOTCH1 binding within the chromatin domain, using all CTCF sites in T-ALL as a background (Additional file 1: Fig. S14e). This evidence concerns the gene NOTCH1 and acute lymphoblastic leukemia.