These findings were corroborated in our two T-ALL patient samples (Fig. 2c–f, Additional file 1: Fig. S4b,c) and in other malignancies such as CRC (P < 0.001 by t-test) (Fig. 2g,h, Additional file 1: Fig. S4d, Additional file 6: Table S5), regardless of presence or absence of CTCF motifs (Additional file 1: Fig. S5). Here, CTCF is linked to colorectal carcinoma.