Of these T-ALL-upregulated genes, those located in chromatin domains with increased interaction between dynamic NOTCH1 sites and T-ALLgained CTCF sites are the ones whose expression is the most downregulated upon CTCF silencing (effect size = − 0.63, P = 0.26) (Additional file 1: Fig. S16f). This evidence concerns the gene NOTCH1 and acute lymphoblastic leukemia.