Differential analysis of our Hi-C data revealed that T-ALLlost sites and T-ALLgained sites have decreased or increased contact frequencies with their flanking regions, respectively, in T-ALL compared to normal T cells, using constitutive CTCF sites as controls (Fig. 2a,b, Additional file 1: Fig. S4a) (P < 0.05 by t-test). This evidence concerns the gene CTCF and acute lymphoblastic leukemia.