CD4 and acute lymphoblastic leukemia: Therefore, we sought to compare our in situ Hi-C [4, 5, 14, 51, 52] data in T-ALL with normal CD4+ T cells to identify genomic regions within the same chromatin domain that interact more frequently with T-ALLgained CTCF sites (Additional file 1: Fig. S14a,b), and used BART [53] to identify putative transcriptional regulators that preferentially bind in these regions.