AIM2 and type 2 diabetes mellitus: In addition, there is accumulating evidence for AIM2 to be involved in sustaining mitochondrial function by detecting mitochondrial DNA (mtDNA) in various human diseases, including cancer and diabetes type 2 (Bae et al. 2019; Qi et al. 2020), as well as in detecting virus-induced oxidized DNA (Moriyama et al. 2020).