Recently, it was demonstrated that human and murine aneurysms express high levels of Tnfsf11/Rankl and are more closely associated with the osteoclast-like catabolic degradation of the aorta than with the osteoblast-like anabolic processes of arterial calcification (Kelly et al. 2019; Takei et al. 2016). Here, TNFSF11 is linked to aneurysm.