In addition, genomic inactivation of the inflammasome components Nlrp3, Casp1 (Caspase-1) and Apc (Apoptosis-associated speck-like protein containing a caspase recruitment domain) reduced the development of AngII-induced aortic aneurysm by inhibiting IL-1β release from bone marrow derived macrophages (Usui et al. 2015). This evidence concerns the gene AGT and aortic aneurysm.